Lawrenceburg, the county seat of Anderson County, is located in the rolling to hilly terrain of Kentucky's famous Bluegrass Region., and is at the junction of US 62, US 127, and KY 44 about three miles west of the Kentucky River.

The site was once known as Kaufman's Station for Jacob Kaufman who established a settlement in 1780.

The town was first called Lawrence for William Lawrence, one of its founders, and was renamed Lawrenceburg in 1827.